Clostridium perfringens is a Gram-positive species of bacteria known for their zoonotic importance and intestinal diseases in various species of animals and humans. C. perfringens produces 7 different toxins and based on these toxins they are categorized into various serotypes, which are commonly called toxinotypes. These bacteria are widely found in the environment and in animals. The major control of these bacteria depends upon vaccination and the use of antibiotics. Vaccines are commonly reported to be less effective because of issues of vaccine failure and lack of proper immune response. On the other hand, daily used antibiotics are also being compromised because of antimicrobial resistance and public health concerns. The severity of these issues demands to search the alternates, and the most suitable alternate is the use of nanoparticles. Various types of nanoparticles, including metallic, metal oxides, and polymeric nanoparticles are being used against C. perfringens for vaccine and antimicrobial drug delivery. Multiple nanoparticles can control C. perfringens-caused intestinal disease by acting on the various cellular processes. Several other nanoparticles can control C. perfringens-caused infections directly by working as delivery agents of various types of vaccines. Research proves that the use of nanoparticles can help to control C. perfringens. Nanomaterials, despite their benefits, however, need to be improved a little especially regarding their synthesis and toxicities.