Yak endometritis is a common postpartum disease that not only harms the reproductive health of yaks but also causes significant economic losses to yak farming. MicroRNAs (miRNAs) have been found to play vital roles in numerous inflammatory diseases. This study aims to investigate the role of miR-184 in modulating LPS-induced inflammation in the yak endometrial epithelial cells and to elucidate the underlying molecular mechanisms involved. Uterine tissues were obtained from three healthy yaks and three yaks diagnosed with endometritis, almost 21 days postpartum. The results demonstrated that inflammatory cell infiltration and structural damage of the endometrium in yak endometritis tissues, with upregulated levels of IL-6, IL-1β, TNF-α expression, and downregulation of miR-184. Similarly, in LPS-induced yak endometrial epithelial cells, miR-184 expression was significantly downregulated, while overexpression of miR-184 significantly declined the levels of IL-6, IL-1β, TNF-α expression and inhibited the activation of the MAPK signaling pathway. Moreover, silencing ELK1 yielded similar results while the targeting relationship between miR-184 and ELK1 was confirmed by dual luciferase reporter assay. Additionally, the overexpression of miR-184 was found to inhibit ELK1 expression. This work reveals the Latent regulatory mechanism of miR-184 in the inflammatory immune response of the yak endometrial epithelial cells and proposes that miR-184 might operate as a useful target for treating inflammation in the yak endometrial epithelial cells.