PAKISTAN VETERINARY JOURNAL

Pak Vet J, 2025, 45(1) 27-35

Histological Patterns of Hepatotoxic Injury in Cavia Porcellus and Methods to Detect Them: A Review

Cassandra Ceccopieri¹*, Jan P. Madej¹, Joanna Skonieczna-Kurpiel², Katarzina Kaleta-Kuratewicz³, Piotr Kuropka³, Jakub Kędzior⁴, Maciej Frelich⁵, Justyna Dziech⁶ and Tomasz Piasecki⁶

¹Department of Immunology, Pathophysiology, and Veterinary Prevention, Wrocław University of Environmental and Life Sciences; ²Department of Food Hygiene and Consumer Health Protection. Norwida street 31, 50-375 Wrocław, Poland;³Division of Histology and Embryology, Department of Biostructure and Animal Physiology, Wrocław University of Environmental and Life Sciences.⁴"SKVet" Klinika Weterynaryjna, Wrocła; ⁵Wrocław Department of Epizootiology and Clinic of Birds and Exotic Animals, Wrocław University of Environmental and Life Sciences; ⁶Center for the Diagnosis and Treatment of Exotic Animals, Veterinary clinic "Zwierzyniec", Wroclaw

*Corresponding author: Cassandra Ceccopieri (cassandra.ceccopieri@upwr.edu.pl)

Abstract

Histology is of invaluable importance in medical science. It allows thorough analysis and characterization of pathological changes in clinical and research studies. The main limit of classic pathology is the correct interpretation of complex morphological data relations and interconnections. For this reason, modern medicine is moving towards automated systems and, ultimately, artificial intelligence. Cavia Porcellus, commonly referred to as Guinea Pig is an excellent model for human medicine, especially for what concerns liver disease. The present review aims to provide a comprehensive guideline of the histological techniques available to produce quality samples for innovative diagnostic tools (computational pathology) on hepatic lipidosis characterization. To date, hepatic lipidosis is indeed one of the most common secondary disorders worldwide without a cure.

To Cite This Article: CeccopieriC, MadejJP, Skonieczna-KurpielJ, Kaleta-KuratewiczK, KuropkaP, KędziorJ, FrelichM, DziechJ and PiaseckiT, 2025. Histological patterns of hepatotoxic injury in Cavia Porcellus and methods to detect them: A Review. Pak Vet J, 45(1): 27-35. http://dx.doi.org/10.29261/pakvetj/2025.137

Abstract

ISSN 0253-8318 (Print)ISSN 2074-7764 (Online)

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)