Diabetes mellitus is a metabolic disease and a major global health concern, characterized by consistently elevated blood glucose levels. Although various treatments are available, they come with certain limitations and side effects. Consequently, herbal alternatives have gained interest for their potential effectiveness in managing diabetes. Chamomile and hibiscus are two herbs known for their health benefits. The study aimed to examine the effects of these herbs both individually, and in combination, on blood glucose levels. Four varieties of value-added peach drinks were developed by incorporating ethanolic extracts of both herbs. In vivo, the administration of chamomile and hibiscus extracts-based drinks was carried out. The study was divided into six groups: G₀ (Negative control), G₁ (Positive control), G₂ (Chamomile added peach drink), G₃ (Hibiscus added peach drink), G₄ (Chamomile and Hibiscus added peach drink), and G₅ (Hyperglycemic rats+ metformin). It was observed that the treatments had a significant impact on all biomarkers by bringing them to normal range, particularly in the combined chamomile and hibiscus treated group. There was an increase in serum insulin and HDL levels along with a decrease in FBG, RBG, and other lipid profile markers such as LDL, TC, and, TG. Normal levels of liver and kidney biomarkers are used as indicators for assessing the safety of chamomile and hibiscus-based drinks. The results of the current study suggest that both chamomile and hibiscus have antidiabetic properties, and their combination had superior outcomes, comparable to the standard drug (metformin). Therefore, these herbs could serve as healthier and more accessible alternatives for managing diabetes, particularly in regions where conventional medicine may not be readily available.

To Cite This Article: Yasin Z, Khan MR, Shabbir MA and Israr B, 2025. Exploring the Therapeutic Potential of Matricaria Chamomilla and Hibiscus Rosa-Sinensis Against Diabetes Mellitus. Pak Vet J. http://dx.doi.org/10.29261/pakvetj/2025.146