LEVAMISOLE TOXICOSIS IN BROILER CHICKS SUFFERING
FROM SUBACUTE TOXICOSIS OF LEAD, SELENIUM OR MONENSIN
Jozef Szarek, Muhammad Zargham Khan1
and Jerzy Szenfeld2
Department of Forensic Veterinary Medicine and
Veterinary Medicine Administration.
University
of
Warmia and Mazury in
Olsztyn, 10-717
Olsztyn,
Poland; 1Department
of Veterinary Pathology.
University
of
Agriculture.
Faisalabad-38040,
Pakistan. 2Department of
Veterinary Hygiene,
Gorzow Wielkopolski,
Poland
Abstract
Broiler chicks of 2 weeks of age were grouped and
fed lead (1200 mg/kg feed), selenium (15 mg/kg feed), selenium plus vitamin E
(15 + 200 mg/kg feed) and monensin (240 mg/kg feed) to induce subacute toxicosis.
One group was kept on basal feed. After four weeks the first subgroup from each
group was perorally given 250 mg levamisole/kg body mass, the second subgroup
was subcutaneously administered 100 mg levamisole/kg body mass and the third
subgroup was given no treatment. The oral administration of levamisole did not
produce any clinical signs. The subcutaneous administration of levamisole
resulted in shivering, partial or complete paralysis and death in different
groups. The higher number of death and severe clinical signs following
levamisole subcutaneous administration were observed in birds subacutely
intoxicated with lead, selenium and monensin compared with control group. This
observation suggests that subacute toxicosis of these substances may alter the
clinical pattern of levamisole toxicosis.