Effect of Tramadol on
Medetomidine and Ketamine Anesthesia in Dogs
W. Choi1,
H. S. Jang1, S. H. Yun, J. S. Park, Y. S. Kwon and K. H.
Jang*
Department of Surgery,
College
of
Veterinary Medicine,
Kyungpook
National
University,
Daegu,
Korea
*Corresponding
author:
khojang@knu.ac.kr
Abstract
The analgesic effects of three different doses of tramadol as a preanesthetic in
medetomidine-ketamine anesthesia in dogs were compared. Twenty-eight healthy
adult
mongrel dogs were used. The dogs
were divided into four groups at random; 1 ml/kg of normal saline, 1, 2 or 4mg
kg-1 of tramadol premedication (group Control, TRA1, TRA2 and TRA4)
was then administered intravenously followed by medetomidine and ketamine
anesthesia. The behavioral changes, the duration of surgical anesthesia, blood
gas parameters (pH, pO2, and pCO2), heart rate, and
systolic/diastolic pressure were observed.
Tramadol (4mg kg-1)
pretreatment significantly
increased the degree of sedation when compared with the control, TRA1 and TRA2
groups at 15 min after tramadol administration (P<0.05). The duration of
surgical anesthesia was significantly increased by tramadol (4mg kg-1)
pretreatment when compared with that of the control group (P<0.05). There were
no significant differences in behavioral changes, blood gas parameters (pH, pO2
and pCO2), heart rate, and arterial pressure among the groups. Tramadol at 4mg
kg-1 did not affect the cardiovascular system and recovery of
anesthesia, but significantly increased the duration of surgical anesthesia with
medetomidine and ketamine. This result suggests that intravenous tramadol at 4mg
kg-1 is a useful preanesthetic agent for extending the surgical level
of anesthesia in medetomidine-ketamine anesthesia in dogs.
Key words:
Dog;
Duration of surgical anesthesia; Ketamine; Medetomidine;
Tramadol