Cardioprotective Potential of Gemmomodified
Extract of Terminalia arjuna
against Chemically Induced Myocardial Injury in Rabbits
Nazish Jahan*, Khalil-ur-Rahman, Shaukat Ali, M.
Rafiq Asi1 and Ajaz Akhtar2
Department of Chemistry and Biochemistry,
University of Agriculture, Faisalabad; 1Nuclear Institute
of Agriculture & Biology, Faisalabad; 2District Head
Quarter Hospital, Faisalabad, Pakistan
*Corresponding author: nazishjahanuaf@yahoo.com
Abstract
The objective of this study was to determine the
comparative cardioprotective potential of bark and gemmomodified extract of
Terminalia arjuna. Cardioprotective
potential was evaluated against isoproterenol induced cardiotoxicity. Both ways
of treatment, curative and preventive were studied. In preventive
cardioprotective potential, rabbits were pretreated with both extracts of
T. arjuna (200 mg/kg) for three weeks and then cardiotoxicity was
induced with isoproterenol. In curative way of treatment isoproterenol was given
for two days and then these cardio intoxicated rabbits were treated with plant
extracts. The activities of cardiac marker enzymes (CK-MB, AST, ALT, and LDH)
and antioxidants enzymes (SOD, CAT) were analyzed in serum and heart tissues of
different groups of experimental rabbits. Isoproterenol significantly (P<0.001)
increased the level of enzymes. The three week prior administration and curative
treatment of T. arjuna extracts
resorted the enzymes and antioxidants level equal to normal. HPLC analysis of
the extracts confirmed the presence of important flavonol and phenolic acids in
both extracts. It can be concluded that gemmomodified and bark extract of
T. arjuna has strong cardioprotective
potential.