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Peracute Infectious Canine Hepatitis
A. H. Cheema*, I. Ahmed, G. Mustafa and A. Aslam
Department of Pathology, University of Veterinary & Animal Sciences, Lahore, Pakistan
*Corresponding Author:


Peracute infectious canine hepatitis (ICH) was diagnosed in two young male dogs out of 56 dead canines presented for necropsy examination during the period of April 2009 to June 2010. These dogs were purebred, one- month old Alsatian and 5-month old Labrador. None of the dogs had received any vaccination or deworming treatment; both had died after illness lasting for six hours and twenty four hours respectively. The dogs had shown signs of depression, anorexia and fever. At necropsy, lymph nodes were swollen, edematous and congested; livers were enlarged, bright red and mottled with numerous small white foci. Petechial hemorrhages were seen in the mucosa. Excessive serosanguinous fluid was present in the abdominal cavities. Histologically, the most significant lesion was necrohemorrhagic hepatitis with single cell necrosis of hepatocytes, lacunose dilation of sinusoids filled with blood and numerous large, solid intranuclear inclusion bodies (IIBs) in the hepatocytes and macrophages. Both eosinophilic and basophilic (amphophilic) inclusions were seen. It has been observed that ICH is re-emerging in some endemic countries. Pet dogs should be regularly protected by effective vaccination.

Key words: Infectious canine hepatitis, Canine adenovirus, Inclusion bodies, Necrohemorrhagic hepatitis


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)