previous page   Pak Vet J, 2012, 32(3): 303-308   next page
Potential Role of Probiotics in Mechanism of Intestinal Immunity
Imran Rashid Rajput and Wei Fen Li*
 Key Laboratory of Animal Nutrition and Feed Sciences, Institute of Feed Science, Ministry of Education, College of Animal Science, Zhejiang University, Hangzhou, P. R. China, 310058
*Corresponding author:


Probiotics are nonpathogenic bacteria exert a constructive influence on health or physiology of the host. Effect of probiotics in the intestinal defense against variety of diseases is well known. The probiotics are involved in the mechanism of intestinal defense, support as antagonist against pathogens, improve intestinal epithelial layer and boost the innate as well as adaptive immunity. However these responses are also exerted by intestinal components. The intestinal components as well as probiotics play a reciprocal role to enhance the immune response of the individual. The possibilities of mechanism of action include the stimulation of epithelial cells, activation of dendritic cells via toll-like receptors (TLRs), conversely produce cytokines. These observations reviewed together advocate that specific immunomodulatory properties of probiotic bacteria should be focusing on mechanism of action via antigen presenting cells (APC).

Key words: Immunity, Mechanism, Probiotics


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)