Potential Role of Probiotics in Mechanism of Intestinal Immunity
Imran Rashid Rajput and Wei Fen Li*
Key Laboratory of Animal
Nutrition and Feed Sciences, Institute of Feed Science, Ministry of
Education, College of Animal Science, Zhejiang University, Hangzhou,
P. R. China, 310058 *Corresponding author:wfli@zju.edu.cn
Abstract
Probiotics are nonpathogenic bacteria exert a constructive influence on health
or physiology of the host. Effect of probiotics in the intestinal defense
against variety of diseases is well known. The
probiotics are involved in the mechanism of intestinal defense, support as
antagonist against pathogens, improve intestinal epithelial layer and boost the
innate as well as adaptive immunity. However these responses are also exerted by
intestinal components. The intestinal components as well as probiotics play a
reciprocal role to enhance the immune response of the individual. The
possibilities of mechanism of action include the stimulation of epithelial
cells, activation of dendritic cells via toll-like receptors (TLRs), conversely
produce cytokines. These observations reviewed together advocate that specific
immunomodulatory properties of probiotic bacteria should be focusing on
mechanism of action via antigen presenting cells (APC).