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Histopathologic Comparison of Radiofrequency and Scalpel Blade on Mice Skin Incisional Wound Healing Model
Banafshe Gholamhoseini*, Soroush Mohitmafi1, Payam Razeghi Tehrani2 and Sattar Noorialeagha3
Department of Pathobiology, 1Department of clinical studies, Veterinary Faculty, Karaj branch, Islamic Azad University, Karaj; 2Department of Anatomy and embryology, Veterinary Faculty, Science and Research branch, Islamic Azad University, Tehran; 3Veterinary Faculty, Karaj branch, Islamic Azad University, Karaj, Iran
*Corresponding author email:


Using a safe and accurate alternative to scalpel blades for various surgical operations has been more considering today. There are many studies about the healing process of various tissues after using different methods like radiofrequency, electro surgery and scalpel blade for the surgical incisions, but choosing the right instrument is very important in cosmetic surgeries.
This study was undertaken to get more histopathologic details about the healing process after using either Radiofrequency (RF) or Scalpel blade as a skin incision method. So, an experimental study was designed in that 12 mice were randomly divided in three groups with the same situation and two different incisions were cut in each mouse on ventral skin by scalpel blade and radio surgical equipment. The skin specimens from scalpel blade incision as group one sample and radiosurgical incision as group two sample were harvested on the same operation day and a weekly manner to day 21.  All samples were stained with Hematoxillin - Eosin and observed under light microscopy. Results showed less tissue contraction at the cutting edge and better collagen alignments in RF incision in comparison to scalpel blade incisions in which having fibrosis and more tissue contraction. These histopathologic findings might be the reason for more elasticity and less scar tissue remaining after skin Radiofrequency surgery.

Key words: Histopathology, Incisional wound healing, Mice, Radiofrequency, Scalpel


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)