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Long-Term Valuation of Oral Mavacoxib in Osteoarthrosic Dogs Using Force Platform Analysis
J.M. Vilar*, M. Morales, A. Santana, M. Batista, F. Miró1 and G. Spinella2
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Trasmontaña S/N, Arucas. 35413. Las Palmas, Spain; 1Department of Compared Anatomy and Pathology, Veterinary Faculty, University of Córdoba, Campus de Rabanales, Ctra. Madrid-Cádiz Km 396 A, Córdoba, Spain; 2Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Germaneto (CZ), Italy
*Corresponding author:


The aim of this study was to assess the efficacy of mavacoxib, a cox-2 inhibitor, to improve the peak vertical force (PVF) and vertical impulse (VI) of lame client-owned dogs with severe coxofemoral osteoarthrosis (OA) by using a force platform. A group of ten canarian presa dogs with lameness and pain for a severe osteoarthrosis due to hip dysplasia were used for this study. Five additional sound dogs of the same breed were used as control groups. A single force platform used to register vertical forces was mounted in a 7 m runway. Mean (± SD) values for speed of dogs were 1.6±0.5 m/s. Data corresponding with 5 valid trials were recorded at walk at day 0, 7, 60 and 180 after starting treatment procedure. The dosing regimen consisted of a loading oral dose of 2 mg⁄ kg to be repeated after 14 days, thereafter the dosing interval was 1 month. OA dogs showed a significant improvement of PVF after two months of about 7% bm in the force exerted by diseased limbs and a significant VI improvement after two months of about 1.6% bm in the VI exerted by diseased limbs. This study clearly showed that dogs treated with mavacoxib increased PVF over time, as soon as seven days after medical therapy, demonstrating a high potential for clinical use in the treatment of lameness associated with OA of hip joint.

Key words: Dog, Force platform, Lameness, Mavacoxib, Osteoarthrosis


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)