Vaccine Induced Antibody Response to Foot and
Mouth Disease in Infectious Bovine Rhinotracheitis Seropositive
Cattle
Murat Şevik
Molecular
Microbiology, Veterinary Control Institute, Meram 42080, Konya,
Turkey *Corresponding author:
dr_muratank@hotmail.com; msevik@kkgm.gov.tr
Abstract
Foot and mouth disease
(FMD) and infectious bovine rhinotracheitis (IBR) are two important infectious
diseases of cattle. Inactivated FMD vaccines are the most powerful tools to
protect animals against FMD. Previous studies showed that recombinant IBR-FMD
viruses protected cattle from virulent
BHV-1 challenge and induced protective levels of anti-FMDV antibodies. FMD is
considered to be endemic in Turkey and inactivated oil adjuvanted vaccines are
used for the immunization of cattle. Previous studies showed that seroprevalence
of IBR in the Turkey’s dairy herd more than 50%. In this study, antibody
response in IBR seropositive cattle following vaccination against FMD was
investigated. IBR seropositive (n=208) and IBR seronegative (n=212) cattle were
vaccinated with oil-adjuvanted bivalent vaccine (containing O1 Manisa,
A22 Iraq FMDV strains). Solid-phase competitive ELISA (SPCE) was used
to measure antibodies produced in cattle. Protective level of antibody against
serotype O was detected in 77.4% and serotypes A in 83.6% of IBR seropositive
cattle. Protective level of antibody against serotype O antibody was detected in
49% and serotypes A in 66.9% of IBR seronegative cattle. The differences between
the protection ratesagainst
both serotype O (P=0.0001) and serotype A (P=0.0001) in IBR seropositive and
seronegative animals were statistically important (Fisher’s exact test, P<0.01).
Results showed that after FMD vaccination, IBR seropositive animals produced
high titres of antibodies than seronegative animals.