A 2-year-old, intact male Siberian Husky was presented with corneal opacity, eye lid swelling, depigmentation, alopecia and erythema predominantly on face. Bilateral uveitis preceded periocular and nasal planum depigmentation. Ancillary tests excluded other systemic diseases. Histopathology of the skin revealed lichenoid interface dermatitis with pigmentary incontinence. Diffuse pyogranulomatous inflammation of the globes was also noted. Based on the clinical signs and characteristic histopathological findings, the dog was diagnosed as uveodermatologic syndrome (UDS). Further treatment was not attempted in this case and the dog was euthanized. This case report describes typical clinical and histopathologic features of UDS in a Siberian Husky.

Key words: Dog, Depigmentation, Uveitis, Uveodermatologic syndrome, Vogt-Koyanagi-Harada syndrome