Disposition Kinetics of Enrofloxacin Following
Intramuscular Administration in Goats
Tariq Hussain, Ijaz javed*, Faqir Muhammad and
Zia-ur-Rahman
Department of Physiology and
Pharmacology, University of Agriculture, Faisalabad, Pakistan
*Corresponding author:
sandhu_drijaz@yahoo.com
Abstract
Enrofloxacin (ENRO) is a
second generation fluoroquinolone that was specially developed for clinically
use in veterinary practice. Most of the previous studies on the pharmacokinetics
of antibiotics have emphasized that the optimal therapeutic dosage of imported
drugs should be determined in the local target species. So the present study was
designed to determine the disposition kinetics of ENRO in healthy adult female
goats under local environment. The ENRO was injected at 5 mg/kg through
intramuscular route. After ENRO administration, blood samples were collected at
different time intervals and analyzed through HPLC. Kinetic parameters were
determined by subjecting the plasma concentration to the two compartment open
model. The value of Cmax and Tmax were 1.03±0.101
µg/ml and 1.47±0.14 hours,
respectively. The values of A and B were (1.46±0.25 and 0.99±0.10 µg/ml), respectively. The mean half-life values of
absorption (t1/2 abs), distribution (t1/2a) and elimination (t1/2β) were
0.88±0.19, 0.69±0.10 and 2.84±0.30 hours, respectively. The values (mean±SE) of
Vd and ClB were 3.96±0.66 l/kg and 0.96±0.10 l/hr/kg,
respectively. The
priming and maintenance doses of ENRO after
intramuscular administration based upon the minimum effective concentration
C°P(min) were determined. The
calculated priming dose for goats, at C°P(min)
0.05 µg/ml, was 4.49 mg/kg for 8 hour dosing intervals while the maintenance
dose for corresponding dosing intervals was 4.29 mg/kg.