Effect
of Fermented Rhus verniciflua
Extract on DNCB Induced-Atopy like Dermatitis in BALB/c Mice
Seung-Yeon Kim, Sileshi Belew Yohannes, Dereje Damte, Seung-Jin
Lee,Md. Akil
Hossain,
Jin-Yoon
Kim,
Man-Hee Rhee,
Joo-Won Suh
and Seung-Chun Park
1Laboratory of Veterinary
Pharmacokinetics and Pharmacodynamics, College of Veterinary
Medicine, Kyungpook National University, Daegu 702-701, South Korea;
2Oriental Medicine Industrial Support center,
Daegu Biotechnopark, Daegu 706-836, Republic of South Korea; 3Center
for Nutraceutical and Pharmaceutical Materials, Division of
Bioscience and Bioinformatics, Science campus, Myongji University,
San 38-2, Namdong, Cheoin-Gu, Yongin, Gyeonggi, 449-728,
Republic of South Korea *Corresponding author:parksch@knu.ac.kr
Abstract
The effect of fermented
Rhus vernicifluaextract on DNCB (1-chloro 2, 4-dinitro-benzene) induced atopic like dermatitis and associated inflammatory responses was evaluated inBALB/c mice. Controlled experiment was performed in 25
BALB/c mice randomly distributed into five groups each
consisted of five mice. DNCB induced-atopy like dermatitis was formed
on the back skin of mice in treatment and positive control groups. The induced-atopy
like dermatitis of mice in treatment
groups was topically treated with fermented Rhus verniciflua extract for two weeks and a day after the last
treatment skin lesion was scored for severity. The mean±SD plasma histamine level of mice in
Rhus verniciflua extract treated
groups was lower than those in DNCB group. Theeosinophil and basophil countsofRhus verniciflua extract treated mice in FRV3 and FRV30 groups were significantly lower than values in DNCB group(P<0.05). The TNF-α level observed for mice in FRV30 group was
significantly lower than DNCB
group(P<0.05).The severity score of the skin lesions revealed significantly lower
values in FRV30 than
DNCB group(P<0.05). The results
obtained in this study suggest the therapeutic potential of fermented Rhus verniciflua extract in reducing progression of
atopic dermatitis.