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Cutaneous epitheliotropic T-Cell Lymphoma with Multiple Metastases in a Dog Diagnosed by PCR to Antigen Receptor Rearrangement Analysis
Ji-SeonYoon1,§, Do-Hyeon Yu2,§, Ru-Hui Song3, Dae Young Kim4 and Jinho Park3*
1Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, Korea; 2Department of Veterinary Laboratory Medicine, College of Veterinary Medicine, Chonnam National University,77 Yongbong-ro, Buk-gu, Gwangju, Korea; 3Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju, Korea; 4Department of Veterinary Pathobiology, University of Missouri, 1600 E. Rollins St, Columbia, Missouri, USA. *Corresponding author:


Herein, a case of canine cutaneous epitheliotropic T cell lymphoma (CETL) with multiple organ metastases is described. An 11-year old female Yorkshire terrier presented with chronic generalized dermatitis and respiratory distress. Multiple erosive plaques and nodules in the skin, enlarged submandibular lymph nodes and tachypnea were noted at the initial presentation. Antigen receptor rearrangement (PARR) analysis by PCR revealed clonal rearrangements from the T-cell receptor gamma (TCRγ) in cells that were fine-needle aspirated from the skin and submandibular lymph node. Histopathological findings in the skin also revealed infiltration of neoplastic lymphoid cells with epithelial tropism. Furthermore, clonal rearrangement from the TCRγ was detected by PARR in the lung nodules. Based upon those findings, the present case was considered as CETL with multiple meta- stases, which has been only rarely reported in canine cases. In this case, diagnosis of CETL and metastases to other organs could be made by PARR analysis alone.

Key words: Cutaneous epitheliotropic T- cell lymphoma, Dog, Metastasis, PCR to detect antigen receptor rearrangement


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)