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Subcutaneous Leiomyosarcoma in a Smad3+/- Mouse
Sang-Hyeob Kim§, Ae-Ri Ji§, Jin-Kyu Park, Ah-Young Kim, Eun-Mi Lee, Eun-Joo Lee, Chang-Woo Min, Kyung-Ku Kang, Myeong-Mi Lee, Soo-Eun Sung, Meeyul Hwang, Dong-Mi Kwak, Tae-Hwan Kim and Kyu-Shik Jeong*
Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea. *Corresponding author:


Subcutaneous leiomyosarcoma is a malignant tumor that originates from smooth muscles in the skin. Herein, we report a case of subcutaneous leiomyosarcoma that occurred in the ear pinna of a 19-month-old male Smad3+/- mouse. On gross examination, the mass extended to the whole ear auricle and obscured the ear opening. The tumor was approximately 10x10 mm in size, ill-circumscribed, and firm with superficial hemorrhage. The cut surface of the mass was grayish-white and solid with focal necrosis and hemorrhage. Histologically, spindle tumor cells with cigar-like nuclei and plump cells with round nuclei formed broad interlacing fascicles. Additionally, the tumor cells invaded adjacent muscles. Immuno- histochemically, the tumor sections had positive reactions for desmine and a-SMA and were partially positive for vimentin while negative for S-100 and myogenin. Based on the results of the examination, we diagnosed this case as subcutaneous leiomyosarcoma.

Key words: Ear auricle, Leiomyosarcoma, Smad3+/- mouse, Subcutaneous


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)