The Role of Chemical and Herbal Antipathogenic
Compounds in the Prevention of Quorum Sensing-Dependent
Pathogenicity of Pseudomonas
aeruginosa - A Review
Hira Hameed and Saiyed I Ahmed*
Institute of Microbiology, University of
Agriculture, Faisalabad-38040, Pakistan *Corresponding author:ahmedsiai@yahoo.com
Abstract
Pseudomonas aeruginosa is an opportunistic pathogen of humans, animals as
well as of plants and the most common Gram-negative bacterium found in
nosocomial infections. Pseudomonas
associated biofilms are highly tolerant to lethal doses of antibiotics. Recent
discoveries of quorum quenching mechanisms use quorum sensing as a potential
antimicrobial target. In this review we discuss the efficacy of different
antipathogenic compounds against gram-negative bacteria in general and against
selected P. aeruginosa strains in
particular. Several strategies for quorum quenching have recently been deployed
and recommended. The first approach is the use of quorum quenching enzymes that
target a broad range of AHLs. Quorum quenching enzymes such as lactonase and
acylase are able to inactivate a wide range of AHLs. The second approach
involves the use of different herbal extracts as quorum quenching compounds
against bacterial virulence. The third approach combines the use of quorum
quenching along with other supplemental treatments, such as antibiotics, to
obtain a synergistic effect in which the quorum quenching compounds deliver the
primary offensive capability to reduce bacterial capacity for pathogenicity and
increase the susceptibility of bacteria to antibiotic treatment. The convergent
approaches are discussed here to elaborate on how new as well as previously
available natural compounds such as active antipathogenic compounds from garlic
and other naturally occurring herbal sources can be utilized in novel ways with
the help of combinatorial chemistry to meet the challenges of increasing threats
from newly emergent and potent drug resistant microbes to treat compromised
individuals particularly with low immunity thresholds.
Key words:
Antipathogenic compounds,
Pseudomonas aeruginosa, Quorum sensing inhibition