Changes in the
Testicular Morphology of Chinchillas
(Chinchilla lanigera)
Implanted with Zeranol
Francisco R Carvallo1,
Carolina A Santibañez2 and Tamara A Tadich2*
1California Animal Health and Food safety
Laboratory, 105 W Central Av, San Bernardino, CA. 92408, USA; 2Department
of Animal Production, Faculty of Veterinary and Animal Sciences,
University of Chile, Santa Rosa 11735, La Pintana, Santiago, Chile;
*Corresponding author:tamaratadich@u.uchile.cl
Abstract
Zeranol is a
semi-synthetic non-steroidal product used by chinchilla breeders to improve fur
quality. The aim of this study was to assess the potential deleterious effects
of zeranol in chinchilla at testicular level. For this purpose, 27 chinchillas
received 6 mg of zeranol and 9 untreated chinchillas were used as control.
Testicles were recovered after routine sacrifice, and the weight, length, width
and testicular perimeter were recorded. Individual information regarding sex,
age, weight at birth, at weaning and at sacrifice of chinchilla was obtained
from the breeders records. The testes were processed for routine histological
evaluation. Treated animals evidenced a significant reduction in testicular
weight, length, width and perimeter. Histological findings included a reduction
in the tubular lumen, loss of epithelium and disappearance of spermatozoids in
the seminiferous tubules. Data suggests that zeranol produces toxic effects on
the testis including degenerative damage in germ cells and Leydig cells, thus
affecting spermatogenesis.