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Histopathologic and Immunohistochemical Features of Disseminated Cutaneous Hemophagocytic Histiocytic Sarcoma in a Maltese Dog
HY Lim1, YG Jang2, JH Ju1, JI Shin1, HW Kim1, NH Kim1, KS Im1, SM Lee2 and JH Sur1*
1Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center; 2Department of Veterinary Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea


A 14-year-old, spayed female, Maltese with multiple nodular skin lesions was presented to a local animal hospital. The nodules were infiltrated by discrete round to polygonal neoplastic cells with large nuclei. Cells having phagocytic activities and multinucleated cells were also present. Immunohistochemically, neoplastic cells were positive for vimentin, S100, lysozyme and CD18 and negative for pancytokeratin, CD3, CD79α, and CD138. Considering histopathologic and immunohistochemical features, the tumor was diagnosed as disseminated cutaneous hemophagocytichistiocytic sarcoma. This is the first report of this disease in a Maltese dog.

Key words: CD18, Dogs, Histiocytic sarcoma, Immunohistochemistry, Neoplasms


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)