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Mannan oligosaccharide supplementation during gestation can enhance porcine reproductive and respiratory syndrome virus (PRRS)-specific antibody levels of sows and their piglets
Sarthorn Porntrakulpipat1,2*, Yaowapa Tuangtananan5, Sutisa Choosing5, Nontawit Yochai5, Pittaya Papirom3, Jatesada Jiwakanon1,2, Peerapol Sukon1,4, Wilairat Chumsing6, Orawan  Boodde6 and Worawidh Wajjwalku7
1Research Group for Preventive Technology in Livestock; 2Department of Veterinary Medicine; 3Department of Pathobiology; 4Department of Anatomy; 5Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand; 6Department of Farm Resources and Production Medicine; 7Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kasetsart University, Kamphaengsaen Nakhonpathom 73140, Thailand; *Corresponding author:


PRRS vaccination is widely used to induce humoral and cell-mediated protective immune (CMI) responses. However, vaccination alone is often insufficient to induce protective immunity. Mannan oligosaccharide (MOS), the outer cell wall of yeast, is known to potentiate both cell-mediated and humoral immunity. This study aimed to evaluate the potentiating effect of MOS on the PRRS-specific antibody production in the sows and subsequent antibody transfer to their offspring.  Thirsty seven sows were randomly assigned to 3 experimental groups: control, supplementation of 400 and 800 ppm MOS in feed during gestation. The PRRS-specific antibody in the sera of sows and their piglets were measured one day before and after parturition, respectively. The results showed that at 400 ppm MOS as feed additive for sows were effectively enhance PRRS-specific antibodies (by ELISA S/P ratio) but not for neutralizing antibody. At 800 ppm MOS in sows’ feed, significantly increase of neutralizing antibody was showed. In conclusion, supplementation of MOS in sows’ feed would be helpful to strengthen the effect of PRRS vaccination.

Key words: Humoral immunity, Mannan oligosaccharide, PRRS


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)