An Endogenous Avian Leukosis Virus Element in the
Genome of Commercial Chickens Showing Emaciation of Unknown Etiology
Bon-Sang Koo, Eun-Ok Jeon, Yeon-Ji Bae, Jong-Suk
Mo, Jong-Nyeo Kim and In-Pil Mo*
Avian Disease Laboratory, College of Veterinary
Medicine, Chungbuk National University, Cheongju, 361-763, Korea;
*Corresponding author: moip@cbu.ac.kr
Abstract
Endogenous viral loci, designated as avian
leukosis virus subgroup E (ALVE), have been found in the genome of commercial
chickens. They sometimes modulate the host physiologic processes by changing the
expression level of host promoters near an integration site. Therefore, the
identification of ALVE locus is necessary for chickens representing abnormal
production traits such as body weight and egg production. In this report, an
ALVE element is commonly identified in the genome of a laying chickens aged 13
weeks and a Korean native chickens aged 10 weeks showing emaciation using an
nested inverse PCR. This element locates near four putative host promoters and
body weight related quantitative trait loci (QTL), which can induce body weight change in chickens. In conclusion, we newly
report the role of an ALVE element for emaciation of laying and Korean native
chickens without the presence of pathogens.
Key words:
Emaciation,
Endogenous avian leukosis virus,
Korean native chicken,
Laying chicken, Quantitative trait loci