Evaluation of D-Dimer Concentrations in
Clinically Ill Dogs with High Risk of Thromboembolic Disease
Min-Hee Kang, Ra-Young Heo and Hee-Myung Park*
Department of
Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk
University, Seoul 143-701, South Korea;
*Corresponding author: parkhee@konkuk.ac.kr
Abstract
Many systemic and metabolic diseases are
associated with increased risk factors that promote the development of thrombus.
But early diagnosis of thromboembolism (TE) may difficult in general practice
due to a lack of noninvasive diagnostic tests. This study was conducted to
compare the plasma concentration of D-dimer, platelet numbers and fibrinogen
degradation products (FDPs) between healthy and clinically ill dogs to evaluate
the usefulness of these assays in detections of hypercoagulability. Eighty-one
clinically ill dogs with high risk of TE and 25 healthy dogs were included in
this study. The plasma D-dimer concentrations were measured through the
immunometric assay, and FDPs concentration was measured by semi-quantitative
latex agglutination assay. Results of the present study indicated D-dimer
concentrations were mainly elevated in immune-mediated hemolytic anemia (IMHA),
liver disease, neoplasia and miscellaneous inflammatory disease group. In
addition, markedly increased D-dimer concentrations (>2000ng/ml) were also
mostly presented in IMHA (33.3%), liver disease (20%), and neoplasia (14.3%)
group. Platelet numbers were significantly different only in neoplasia and
endocrine disorder group. The plasma concentrations of D-dimer and FDPs of
clinically ill dogs were mainly increased compared to healthy dogs. However,
almost 30% of dogs with normal D-dimer value showed positive FDP assay results
in both healthy and disease group. Concurrently performed plasma D-dimer and
FDPs assays can be rapid screening tests for hypercoagulability in canine
patients; however, cautious interpretation is required and should not be used as
single diagnostic tool for TE.