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Use of Mesenchymal Stem Cells from Canine Bone Marrow Associated with the Use of Metallic Implants in the Repair of Distal Radius and Ulna Fractures in Toy Breed Dogs
Adriano Barile Dora, Daniel Tonin Benedetti, Diego Carvalho Viana and Paula Fratini*
Department of Surgery - sector Anatomy, School of Veterinary and Animal Science, University of Sao Paulo, Sao Paulo, Brazil; *Corresponding


Cell therapy has been an effective tool for the treatment of several animal diseases in experimental and clinical studies, including osteogenic stimulation for the treatment of non-union and repair fractures of distal radius and ulna in dogs. There are many advantages of using stem cells since this differentiated cell type has high proliferation capacity, self-renewal, production of different cell lines and tissue regeneration. These cells are present in embryos and can be collected from umbilical cord and bone marrow. The aim of this study was to perform a clinical and radiographic evaluation of dogs with fractures of distal radius and ulna after surgery and treatment of fractures with stem cells from canine fetuses’ bone marrow. Radiographic evaluations showed bone regeneration from 45 days post-surgery in both the groups, only with conventional surgery and implant and also in the conventional surgery group with implants associated with stem cells. Thus, cell therapy can be a favorable tool to assist in bone healing of distal fractures of radius and ulna, however, details on the quantity of applied cells and routes of administration need to be studied in more detail.

Key words: Dogs, Fractures, Non union, Stem cell


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)