Use
of Mesenchymal Stem Cells from Canine Bone Marrow Associated with
the Use of Metallic Implants in the Repair of Distal Radius and Ulna
Fractures in Toy Breed Dogs
Adriano Barile Dora, Daniel Tonin Benedetti, Diego Carvalho Viana and Paula Fratini*
Department of Surgery - sector Anatomy, School of Veterinary and
Animal Science, University of Sao Paulo, Sao Paulo,
Brazil;
*Corresponding author:fratini@usp.br
Abstract
Cell therapy has been
an effective tool for the treatment of several animal diseases in experimental
and clinical studies, including osteogenic stimulation for the treatment of
non-union and repair fractures of distal radius and ulna in dogs. There are many
advantages of using stem cells since this differentiated cell type has high
proliferation capacity, self-renewal, production of different cell lines and
tissue regeneration. These cells are present in embryos and can be collected
from umbilical cord and bone marrow. The aim of this study was to perform a
clinical and radiographic evaluation of dogs with fractures of distal radius and
ulna after surgery and treatment of fractures with stem cells from canine
fetuses’ bone marrow. Radiographic evaluations showed bone regeneration from 45
days post-surgery in both the groups, only with conventional surgery and implant
and also in the conventional surgery group with implants associated with stem
cells. Thus, cell therapy can be a favorable tool to assist in bone healing of
distal fractures of radius and ulna, however, details on the quantity of applied
cells and routes of administration need to be studied in more detail.