Analgesic Effects of Lidocaine and Fentanyl Alone
or in Combination Undergoing Ovariohysterectomy in Female Dogs
Dezhang Lu1,2, Chenchen Wu1, Yupeng Yin1*
and Xinwu Ma1,2*
1Department of Clinical
Science, College of Veterinary Medicine, Northwest A&F University,
Yangling, Shaanxi 712100, P.R. China; 2Department of
Veterinary Surgery, Xi’an Teaching Hospital, Northwest A&F
University, Xi’an, Shaanxi 710068, P.R. China *Corresponding author:jason09999@163.com;
coolyyp@163.com
Abstract
In this study, the analgesia effects of
intravenous injection either of lidocaine, fentanyl, or their combination were
compared in dogs undergoing ovariohysterectomy. Forty-eight dogs were randomly
assigned into three groups. Anesthesia was induced with 6 mg/kg propofol and
maintained with 2% (vaporizer dial setting) isoflurane. Animals received
lidocaine (4 mg/kg), fentanyl (3 μg/kg), and their combination after 15 minutes
of induction. Heart rhythm, respiratory rhythm, blood pressure, rectal
temperature, subjective pain scores and arterial blood-gas were measured at same
time. Cardiopulmonary variables changed after injection, and some of them had
significant differences compared with baselines at the moment of extubation. The
maximal subjective pain scores were recorded at three hours after extubation,
but rescue analgesic was not required at this study. Though values regarding
blood gas changed after intravenous administration
of agents, significant differences were not found between groups
at any of the time-points. Both drugs and their combination provided adequate
analgesia undergoing ovariohysterectomy in dogs. No side effects were observed,
no rescue analgesic was required.