Zu Quan FU, Jiao Yao, Bo Liu, Lv Qiao XIA, Xiao
Li Liu, Chang Qin GU, Wan Po Zhang, Guo Fu Cheng and Xue Ying Hu*
Department of Veterinary
Pathology, Huazhong Agriculture Univerisity, Hubei, China, 430070 *Corresponding author: hxying@mail.hzau.edu.cn
Abstract
A 14-year-old female Mongrel dog presented with
multiple, cherry-sized, well-circumscribed papillary masses on the right upper
hard palate and gingival area. Histologically, the masses contained biphasic
components composed of hyperplastic squamous epithelium forming papillary
fronds, and underlying tortuous dilated ducts and cysts. Immunohistochemistry
demonstrated that both squamous and ducts epithelium were pan-Cytokeratin (pCK)
positive, but they were negative of Alpha smooth muscle (α-SMA), Vimentin and
Protein 53 (P53). Duct epithelial cells were strong positive of Cytokeratin 8&18
(CK8&18), Ki-67, and weakly positive of S-100, whereas squamous component were
strong positive of Cytokeratin 5&6 (CK5&6). Sialadenoma
papilliferum (SP) was diagnosed based on clinical sign, gross and
histopathological findings, and biochemistry.