1Department
of Chemistry; 2Department of Biochemistry, University of
Agriculture, Faisalabad, Pakistan *Corresponding author: nazishjahanuaf@yahoo.com
Abstract
In the present research, the anti-arrhythmic
potential of Coriandrum sativum
(seeds) was evaluated in BaCl2 induced tachycardia and KCl induced
bradycardia in rats. Heart rate and electrocardiogram (ECG) was recorded during
the experimental period. The BaCl2 increased the heart rate from
111/min to 157/min while KCL decreased the heart rate from 112/min to 60/min in
the rats of positive control groups. ECG patterns also confirmed the tachy- and
brady-arrhythmia in the rats of both positive control groups. The changes in
biochemical cardiac biomarkers (CK-MB, LDH, AST, and ALT) were also the studied
parameters.The level of cardiac
biomarkers was significantly elevated in the serum of positive control rats as
compared to their respective absolute controls. In case of both curative and
preventive mode of treatment the elevated levels of enzymes, cardiac biomarkers
were significantly reduced. Electrocardiogram (ECG) pattern revealed that the
studied plant possesses a very good anti-arrhythmic potential in case of
curative mode of treatment. The antiarrhythmic potential through preventive mode
of treatment was also encouraging, but comparatively less than the curative mode
of treatment. Anti-tachycardial potential of
C. sativum was comparable with standard drug while, recovery in
bradycardia was relatively slow than standard drug. Gross pathology and ECG
pattern of base line group confirmed the innoxious nature of
C. sativum seeds. Treatment of rats
with Coriandrum sativum (100 mgkg-1
BW) normalized the heart rate and attenuated the cardiac arrhythmia.