Comparative Study on Sevoflurane Anesthesia Alone
and Combined with Partial Intravenous Anesthesia using
Dexmedetomidine in Healthy Horses
Galina Petkova Simeonova*, Dinko Nedev Dinev and
Makram Uasef Sleiman
Department of Veterinary Surgery, Faculty of
Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria *Corresponding author: galinavet@abv.bg
Abstract
Partial intravenous anesthesia (PIVA) seems to be
a good alternative to either inhalational or total intravenous anesthesia
regarding their adverse cardiopulmonary, respiratory, and other body systems
effects. Many protocols have been recently investigated in order to find a
safer, more effective one. The aim of the present study was to evaluate whether
the addition of dexmedetomidine constant rate infusion (CRI) to sevoflurane
anesthesia would have any beneficial influence on sevoflurane requirements,
cardiorespiratory function, acid-base status, blood gases, hemocoagulation and
recovery in healthy horses. Six horses were submitted to either sevoflurane
anesthesia (group S) or PIVA using sevoflurane and dexmedetomidine (group SD).
The main cardiovascular and respiratory parameters were recorded every 5 minutes
throughout 3 hours. Acid-base and hemocoagulation variables, and blood gases
were measured at the beginning and in the end of each anesthesia. Times to
recovery and its quality were scored. Analysis of variance (ANOVA) for repeated
measurements, t-test for normally distributed data or Mann-Whitney test for not
normally distributed variables, one-way ANOVA, post-hoc Fisher test, and
Wilcoxon signed rank test were used for statistical analysis. In conclusion,
PIVA using dexmedetomidine CRI decreased slightly sevoflurane requirements in
healthy horses. Sevoflurane anesthesia with or without dexmedetomidine CRI
maintained stable cardiovascular status. Respiratory depression, increased blood
lactate levels and unchanged coagulation parameters (except for APTT) were
observed in the two anesthesia protocols. The recovery times were short and
comparable in both groups but recovery quality was better in the SD group.