Testicular Leiomyosarcoma in an SMP30 Knockout Mouse
Jin-Kyu Park and Kyu-Shik Jeong*
Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu,
702-701, Republic of Korea;
*Corresponding author:
jeongks@knu.ac.kr
Abstract
Reports of testicular leiomyosarcoma are
extremely rare in the veterinary literature. Here we report a case of testicular
leiomyosarcoma occurring in a 32-weeks-old male senescence marker protein 30
(SMP30) knockout mouse. Grossly, a testicular mass completely replaced the right
testis. The mass had a diameter of 1.6×0.9cm, and was well-encapsulated and
firm. The cut surface showed heterogeneous white and yellow-brownish components
with multifocal hemorrhages. Microscopically, the mass was composed of interlacing bundles of
neoplastic cells characterized by a spindle-shaped appearance
with elongated blunt-end nuclei and frequently observed mitotic figures. Immunohistochemically, the neoplastic cells showed strong positivity for
vimentin and α-smooth muscle actin. Finally, present case was diagnosed as testicular
leiomyosarcoma in an SMP30 knockout mouse.