The Dedifferentiate Tumor of
the Bursa of Fabricius and the Intestinal Mucosa Associated Lymphoid
Tissue in Quail (Coturnix
coturnix): Case Report
C Solcan, M Spataru, C Spataru, V Floristean* and
G Solcan
University of Agricultural Science and Veterinary
MedicineIon Ionescu de la
Brad, Faculty of Veterinary Medicine, M. Sadoveanu Alley 8, Iasi,
700489, Romania *Corresponding author: vfloristean@uaiasi.ro
Abstract
After examination of 150 female quails, four of
them showed the dedifferentiate tumor of the bursa of Fabricius. To the
periphery, it consists of the dedifferentiate hemangiosarcoma and liposarcoma,
the predominant area being constituted from lymph nodes of variable sizes. Among
the lymphocytes rows the extensions of the reticular cells appeared positive for
MHC II antibody. The lymphocytes showed the negativity to p53. The Bcl-2 marker
manifested a limited positive reaction only in certain follicles. IgA and IgM
markers showed the relatively low level of positivity in lymph nodes. Only the
dense cords of the pleomorphic melanocytes manifested the positivity to Bcl-2.
At the junctions between ventriculus and duodenum; ileum and cecum, especially
in serosa, there were identified lymphocytes positive to MHC II, Bcl-2 and p53
markers surrounded by clusters of lipoid cells located inside the intestine
wall. These structures were metastases of the dedifferentiate tumor of the bursa
of Fabricius.
Key words:
Bursa of Fabricius,
Dedifferentiate tumor,
Hemangiosarcoma,
Immunohistochemistry,
Liposarcoma, Quail