This paper describes case of psoroptic mange in a herd consisting of 45 sheep and 15 cattle. Single species of mite, Psoroptes ovis, was identified in superficial skin scrapings, treated with 10% KOH, of all sheep and cattle. For treatment purpose, affected animals were placed in four groups (three sheep groups each having 15 sheep and fourth one consisting of 15 cattle) and control group consisted of 15 healthy animals. Two doses of Doramectin, Ivermectin, Trichlorofan and Ivermectin were injected/poured on at 14 days interval. Significantly different mean recovery response was measured in groups (2 and 4) treated with ivermectin from all others at 7^th day after treatment (P<0.05).  All members of groups 2 and 4 were recovered completely at day 14 post-treatment and clinical signs were diminished. It was concluded that ivermectin is quite effective for treatment of Psoroptic mange in sheep and cattle as well.

Key words: Cholistan, Ivermectin, Psoroptes ovis, Sheep