Bisphenol-A (BPA) Alters Plasma Thyroid Hormones
and Sex Steroids in Female Pakistani Major Carp (Catla catla; Cyprinidae)
Mehwish Faheem*1, Saba Khaliq2,
Hafiz Usman Ahmad2 and Khalid Parvez Lone2
1Department
of Zoology, Government College University, Lahore, Pakistan; 2Department
of Physiology & Cell Biology, University of Health Sciences, Lahore,
Pakistan *Corresponding author: mehwishfaheem@gcu.edu.pk; mehwish_faheem@hotmail.com
Abstract
In teleosts, steroid synthesis is mainly
controlled by hypothalamus-pituitary-gonadal (HPG) axis. A number of compounds
released into aquatic environment that have potential to interfere with fish
endocrine system. These endocrine disturbing chemicals (EDCs) can disturb
piscine endocrine system at every level by interference with HPG axis. Bisphenol-A
(BPA) is an estrogenic endocrine disrupting chemical used in production of
polycarbonate plastic and epoxy resins. The present study was aimed to
investigate the effects of BPA on level of steroid and thyroid hormones in a
fresh water cyprinid, Catla catla.
Virgin female C. catla, two years of
age, were exposed to graded concentration of BPA (10,100 and 1000µg/l) for 14
days, after stipulated time fish were bled and hormone titers were estimated.
Plasma level of estradiol significantly increased in response to 100 and
1000µg/l BPA exposure. A significant decrease in plasma testosterone,
triiodothyroxin (T3), thyroxin (T4) was recorded after 14 days BPA exposure.Plasma follicle-stimulating hormone (FSH) levels showed significant
increase only at 10μg/l BPA exposure. Significant increase in plasma luteinizing
hormone (LH) was observed in fish exposed to 1000µg/l of BPA. Change in plasma
sex hormone and gonadotropin levels may cause subsequent reproductive
dysfunction by interfering with the feedback regulatory mechanisms of the
HPG-axis.