In present study, anti-diabetic effect of camel milk and black seed oil, separate and combined, on hematobiochemical and histological parameters of selected organs was evaluated. Forty female albino rats were split into 5 groups (n=8): Group A was kept as normal. Alloxan^® was administered in groups B to E for induction of diabetes. Group B was considered diabetic control while group C, D and E were offered camel milk @ 40ml/kg/day, black seed oil @ 0.8ml/day in separate and combination respectively for 30 days. Weekly blood glucose level was monitored. Animals were slaughtered to collect: blood for hematology and serum analysis and tissues for histology. Microscopy of H&E stained tissues was done at 100X to observe degenerative alterations in liver, kidneys and uterus. Least Significance Difference (LSD) test was used to compare the group means. Diabetes showed significant (P<0.05) impact on all parameters studied except uterine histometry which remained unaltered. Camel milk and black seed oil, separate or combined, significantly (P<0.05) recovered diabetic altered hematological (RBC, PLT, WBC, MCV, Hb, lymphocyte (%), MCH) and serological parameters (AST, ALT, Creatinine, BUN). Combined therapy of these agents showed more significant (P<0.01) reduction in blood glucose level as compared to their individual effects. Histological observations demonstrated that camel milk and black seed oil improved the altered histology of liver and kidneys towards normal. Hence, camel milk and black seed oil collectively have potential to restore diabetogenic hematological and serological parameters with capacity to constraint the diabetic encounter on liver and kidneys’ histology.

Key words: Black seed oil, Camel milk, Diabetes, Histology, Serum profile