Nephrotoxic and Prooncogenic Effects of
Monosodium Glutamate in Quail (Coturnix
japonica)
C
Solcan1, E Costachescu2, E Fotea2,
R Malancus3, G Pavel3 and G Solcan4*
1Department of Histology and Molecular Biology; 2Department
of Management of Animal Productions; 3Department of
Physiology; 4Department of Clinics, Ion Ionescu de la Brad” University of Agricultural
Sciences and Veterinary Medicine, 8 Mihail Sadoveanu Alley, 700489,
Iasi, Romania*Corresponding author: gsolcan@uaiasi.ro
Abstract
The study aims to assess the effect of monosodium glutamate (MSG) in Japanese
quail (Coturnix japonica). It was done
on one hundred and thirty-four quails were divided into four groups: one control
group (C) and three experimental groups that received during 30 days a daily
dose of 10 g (E1), 30 g (E2) and 50 g (E3) MSG/kg feed, respectively. It
was noticed to
the end of the experiment an improvement in growth performance for the group E1,
while in groups E2 and E3 higher feed consumption and decreased average daily
weight gain was observed. Hematological studies revealed significant changes for
the groups E2 (decreased PCV, reduction of Hf/Lf ratio, due to heterophils
decrease) and E3 (increased Hf/Lf ratio due to heterophils increase and
lymphocytes reduction) compared to the control group (C). Hematobiochemical
studies revealed significant increases in blood urea nitrogen (BUN), creatinine
and uric acid in quails from E2 and E3. In the kidneys of birds from E2 and E3
birds, was observed a degradation of cortical and medullar cytoarchitecture and
also necrosis and vacuolization of proximal and distal convoluted tubules cells
were observed. Positive nuclei were showed by P53 staining, both in proximal and
distal convoluted tubules, collecting tubules epithelium but also in some of
Malpighi corpuscles. Bcl-2 revealed positivity in the cytoplasm of the proximal
and distal convoluted tubules cells in varying proportions depending on the
group suggesting the prooncogenic potential of MSG in dosages that exceed 30g/kg
feed.
To Cite This Article: Solcan C, Costachescu E,
Fotea E, Malancus R, Pavel G and Solcan G,
2018. Nephrotoxic and prooncogenic effects of monosodium glutamate in quail (Coturnix
japonica). Pak Vet J, 38(1): 29-34.
http://dx.doi.org/10.29261/pakvetj/2018.006