The aims of the present work were to study the pharmacokinetics of marbofloxacin 10% solution after single i.m. administration at doses of 6, 8, 10 mg/kg b.w. in swine of 20 weeks of age, to estimate the PK/PD indices using bibliographic MIC₉₀ values and to assess the tolerability of the drug. Marbofloxacin C_max increased in a dose dependent manner, however animals receiving the 10 mg/kg b.w. dose revealed slightly lower AUC_i compared to those receiving 8 mg/kg b.w. This suggests a potential alteration of the elimination mechanisms, evidenced by Cl_tot values after administration of the three dosages. According to the results of the study, the three tested dosages are well tolerated and active for 2-3 days against the most common pathogens in swine. In particular, 8 mg/kg appeared to be the most suitable dose, since 6 mg/kg might be insufficient against the less susceptible pathogens and 10 mg/kg seemed not to provide any advantage.

To Cite This Article: Rambaldi J, Barbarossa A, Morbidelli E and Zaghini A, 2018. Pharmacokinetic/ pharmacodynamic evaluation of marbofloxacin for common pathogens in swine following single intramuscular administration of different doses. Pak Vet J, 38(2): 222-224. http://dx.doi.org/10.29261/pakvetj/2018.046