Hematological and Serum Biochemical Effects of
Aflatoxin B1 Intoxication in Broilers Experimentally Infected with
Fowl Adenovirus-4 (FAdV-4)
Muhammad Noman Naseem1, Muhammad
Kashif Saleemi1*, Rao Zahid Abbas2, Ahrar Khan1,
Aisha Khatoon1, Shafia Tehseen Gul1, Muhammad
Imran1, Zia-ud-Din Sindhu2 and Asim Sultan3
1Department
of Pathology, University of Agriculture Faisalabad; 2Department
of Parasitology, University of Agriculture Faisalabad; 3Livestock
and Dairy Development Department, Faisalabad, Punjab Pakistan *Corresponding author: drkashif313@gmail.com
Abstract
Mycotoxins contamination of poultry feeds is a
global issue faced by the poultry industry due to increase demand and provision
of poor quality cereal grains. The current experimental study was designed to
investigate concurrent administration of aflatoxins and fowl adenovirus in
commercial broilers. Fowl adenovirus-4 is re-emerging in Pakistan including its
horizontal and vertical transmission. A total of 120 one day old birds were
divided into six equal groups (A-F). Groups A was kept as control, B and C were
fed AFB1 100 and 200 ppb respectively, whereas group D, E and F were
administered FAdV-4, AFB1 100 +FAdV-4, AFB1 200 + FAdV-4, respectively.
Hemoglobin concentration, erythrocytic count and leukocytic count of all the
groups significantly decreased as compared to control group. Hematocrit (%) of
group C, E and F was significantly lower as compared to group A. Serum
concentration of creatinine, urea, ALT, AST
and GGT significantly increased in all groups as compared to control group in a
dose dependent manner. It might be concluded that AFB1 intoxication in FAdV-4
infected birds potentiated the hepatic and renal damage as indicated by
increased values of urinary and hepatic biomarkers.
To Cite This Article:
Naseem MN, Saleemi MK, Abbas RZ, Khan A, Khatoon
A, Gul ST, Imran M, Sindhu ZUD and Sultan A, 2018. Hematological and serum
biochemical effects of aflatoxin B1 intoxication in broilers experimentally
infected with fowl adenovirus-4 (FAdV-4). Pak Vet J, 38(2): 209-213. http://dx.doi.org/10.29261/pakvetj/2018.028