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Clinico-Pathological Evaluation and Treatment Outcomes of Canine Transmissible Venereal Tumor Using Three Different Protocols
Mohamed Fathi1, Mohamed Ashry1,2*, Khaled M. Ali3, Azza Hassan4 and Amr F Elkarmoty5
1Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt
2Laboratory of Mammalian Reproductive Biology, Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA; 3Department of Surgery, Anesthesiology and Radiology; 4Department of Pathology; 5Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt; *Corresponding author:


The objectives of this study were to demonstrate the clinical and pathological findings of TVT, and to investigate the outcomes of three management protocols including chemotherapy with vincristine, surgical intervention and combination of surgery and chemotherapy under field conditions in Egypt. This study was conducted on 104 dogs of different ages and breeds (Male=51, Female=53). Diagnosis of TVT was evident by gross clinical manifestations, ultra-sonographic, and histopathological examination. Dogs were allocated to 3 groups. Group 1 (n=36), was treated by chemotherapy with IV injection of vincristine sulfate for 4 weeks, complete regression of the tumor nodules was observed in 29 cases (80.55%), while 7 cases (19.45%) had incomplete regression at the end of 4 weeks, group 2 (n=34), was treated by surgical de-bulking of the tumor nodules, complete regression was observed in 19 (55.88%) whereas 15 cases (44.12%) showed incomplete regression and recurrence of the tumor nodules and  group 3 (n=34), was subjected to surgical intervention followed by vincristine treatment, 31 dogs (91.17%) showed complete regression with only 3 cases (8.83%) were not completely recovered, suggesting that surgical treatment coupled with vincristine chemotherapy is the most efficient protocol of TVT treatment in dogs.

To Cite This Article: Fathi M, Ashry M, Ali KM, Hassan A and Elkarmoty AF, 2018. Clinico-pathological evaluation and treatment outcomes of canine transmissible venereal tumor using three different protocols. Pak Vet J, 38(2): 204-208.  


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)