Clinico-Pathological Evaluation and Treatment Outcomes of Canine
Transmissible Venereal Tumor Using Three Different Protocols
Mohamed Fathi1,
Mohamed Ashry1,2*, Khaled M. Ali3, Azza Hassan4
and Amr F Elkarmoty5
1Department
of Theriogenology, Faculty of Veterinary Medicine, Cairo University,
Giza 12211, Egypt
2Laboratory of Mammalian Reproductive Biology,
Department of Animal Science, Michigan State University, East
Lansing, MI 48824, USA; 3Department of Surgery,
Anesthesiology and Radiology; 4Department of Pathology;
5Department of Anatomy and Embryology, Faculty of
Veterinary Medicine, Cairo University, Giza 12211, Egypt;
*Corresponding author:
ashry@cu.edu.eg
Abstract
The objectives of this study were to demonstrate
the clinical and pathological findings of TVT, and to investigate the outcomes
of three management protocols including chemotherapy with vincristine, surgical
intervention and combination of surgery and chemotherapy under field conditions
in Egypt. This study was conducted on 104 dogs of different ages and breeds(Male=51, Female=53). Diagnosis of TVT was evident by gross clinical
manifestations, ultra-sonographic, and histopathological examination. Dogs were
allocated to 3 groups. Group 1 (n=36), was treated by chemotherapy with IV
injection of vincristine sulfate for 4 weeks, complete regression of the tumor
nodules was observed in 29 cases (80.55%), while 7 cases (19.45%) had incomplete
regression at the end of 4 weeks, group 2 (n=34), was treated by surgical
de-bulking of the tumor nodules, complete regression was observed in 19 (55.88%)
whereas 15 cases (44.12%) showed incomplete regression and recurrence of the
tumor nodules and group 3 (n=34), was
subjected to surgical intervention followed by vincristine treatment, 31 dogs
(91.17%) showed complete regression with only 3 cases (8.83%) were not
completely recovered, suggesting that surgical treatment coupled with
vincristine chemotherapy is the most efficient protocol of TVT treatment in
dogs.
To Cite This Article: Fathi M, Ashry M, Ali
KM, Hassan A and Elkarmoty AF, 2018. Clinico-pathological evaluation and treatment
outcomes of canine transmissible venereal tumor using three different protocols. Pak Vet J, 38(2): 204-208. http://dx.doi.org/10.29261/pakvetj/2018.044