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High Protein Diet Improves Biochemical and Metabolic Hormonal Profile in Alloxan-Induced Diabetic Rats
Humaira Muzaffar, Muhammad Naeem Faisal*, Junaid Ali Khan and Bilal Aslam
Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan
*Corresponding author:


Diabetes mellitus is a metabolic disorder characterized by high blood glucose level due to defective insulin secretion or action and is considered one of the major concerns to human health all over the world. Current study was planned to assess the effects of protein rich diet on body weight, glycemic control, insulin levels in hyperglycemic rats. For this purpose, high protein diet (45% or 55% fish protein rich in omega 3 fatty acids) was administered to alloxan-induced diabetic rats for a period of 28 days. Blood samples were collected for monitoring glucose level, serum insulin level and thyroid hormone levels. Alloxan administration resulted in reduced body weight, increased blood glucose, leptin while decreased insulin, amylin, glucokinase, thyroid stimulating hormone (TSH), triiodothyronin (T3) and thyroxin (T4) levels. High protein diet significantly restored body weight and showed significant anti-diabetic effect by reducing serum glucose and increasing serum insulin level in comparison to positive control (diabetic) group. Use of high protein diet also normalized serum amylin, leptin, GCK, T3, T4 and TSH.  In sum, these results indicated the anti-hyperglycemic potential of high protein diet in alloxan-induced diabetic rat model.

To Cite This Article: Muzaffar H, Faisal MN, Khan JA and Aslam B, 2019. High protein diet improves biochemical and metabolic hormonal profile in Alloxan-induced diabetic rats. Pak Vet J, 39(2): 231-235.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)