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Combination Chemotherapy with Firocoxib Induces Reduction of Regulatory T Cells in Dogs with Multicentric B Cell Lymphoma
Letícia Abrahão Anai1, Thiago Demarchi Munhoz2, Lívia Maria Souza Semolin1, Denise Morais da Fonseca3, Paulo César Jark4, Felipe Augusto Ruiz Sueiro5, Sabryna Gouveia Calazans6, Mirela Tinucci Costa1 and Aureo Evangelista Santana1
1Clinical Veterinary Department, College of Agricultural and Veterinary Sciences, São Paulo State University “Júlio de Mesquita Filho” (UNESP), Jaboticabal, São Paulo, Brasil; 2Clinical Veterinary Department, Barão de Mauá University, Ribeirão Preto, São Paulo, Brasil.3 Immunology Department, Medicine College, São Paulo State University, São Paulo, Brasil; 4Clinical Veterinary Department, Unicastelo, Descalvado, São Paulo, Brasil; 5VetPat, Campinas, São Paulo, Brasil; 6Clinical Veterinary Departamente, University of Franca, Franca, São Paulo, Brasil
*Corresponding author:


The aim of this study was to quantify T cells (CD4+, CD8+ and Treg), in dogs with multicentric lymphoma treated with a conventional CHOP protocol or with one in which firocoxib was used instead of prednisone. Twenty-one dogs with lymphoma were divided into two treatment groups (G1=10 and G2=11): those that received the conventional CHOP protocol for 19 weeks (CHOP group) and those that received CHOP protocol with firocoxib instead of prednisone (CHOF group). Twelve clinically healthy dogs were used as control. The percentage of Treg cells were three times greater in animals with lymphoma than in the control group (P<0.05). During treatment, the reduction in Treg cells was slower in animals treated with firocoxib than in those that received prednisone. No significant difference (P>0.05) was observed in survival time between the two treatment protocols. It can be concluded that the use of firocoxib instead of prednisone in CHOP protocol can induce Treg cell remission in dogs with multicentric lymphoma without interfering with the survival time of these animals.

To Cite This Article: Anai LA, Munhoz TD, Semolin LMS, da Fonseca DM, Jark PC, Sueiro FAR, Calazans SG, Tinucci-Costa M and Santana AE, 2019. Combination chemotherapy with firocoxib induces reduction of regulatory T cells in dogs with Multicentric B cell lymphoma. Pak Vet J, 39(2): 226-230.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)