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Pak Vet J,
2019,
39(3):
365-370
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Garcinia Mangostana Extract Enhances Skin Epithelialization
in Rat Induced Burn Injury |
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Marisca Evalina Gondokesumo1,2#,
Bambang Pardjianto3,
Kusworini Handono4, Sutiman Bambang Sumitro5,
Wahyu Widowati6,
Okta Wismandanu7, Tyagita Hartady7,
Aziiz Mardanarian
Rosdianto7, Hanna Goenawan7,8,9, Ronny Lesmana7,8,9,
Nasrul Wathoni10
and
Unang Supratman9,11 |
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1Biomedical Sciences Doctoral Study, Faculty of Medicine,
Brawijaya University, Malang, Indonesia; 2Faculty of Pharmacy, University of Surabaya, Surabaya,
Indonesia; Department of Plastic Surgery Saiful Anwar General
Hospital, Faculty of Medicine, Brawijaya University, Malang,
Indonesia; 4Department of Clinical Pathology,
Faculty of Medicine, Brawijaya University, Malang, Indonesia; 5Biology
Department, Faculty of Mathematics and Natural Sciences, Brawijaya
University, Malang, Indonesia; 6Faculty of Medicine,
Maranatha Christian University, Bandung, Indonesia; 7Veterinary
Medicine Study Program, Universitas Padjadjaran, Bandung, Indonesia;
Physiology Division, Department of Biomedical Sciences, Faculty of
Medicine, Universitas Padjadjaran,
Bandung, Indonesia; Division of Biological Activity, Central
Laboratory, Universitas Padjadjaran, Bandung, Indonesia; Department of Pharmaceutics and
Pharmaceutical Technology, Faculty of Pharmacy, Universitas
Padjadjaran, Bandung, Indonesia; 11Department
of Chemistry,
Faculty of Mathematics and Natural Sciences,
Universitas Padjadjaran,
Bandung, Indonesia
*Corresponding author:
mariscaevalina@gmail.com |
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Abstract
Mangosteen has several important elements for biological activities such as anti-oxidant,
anti-inflammatory, anti-bacterial and anti-cancer. There are γ-mangostin, α-mangostin,
flavonoids, saponins, and tannins which could stimulate the collagen deposition
and accelerate wound healing process. Burn injury cause deep wound in the skin
and often cause cicatrix and
keloid scar on the skin. However, there is limited
information about role of mangosteen in skin wound healing after burn injury.
Fifty 10 week-old male rats, were subjected to burn injury using
automatic temperature control. Burn
injury was created by
direct contact of hot plate
(170°C) for 15 seconds on
rats’ inter scapula region.
We elaborated the role of extract mangosteen in
skin wound healing by applying daily gel contain with active compound derived
from mangosteen.
There
was no significant weight change
during treatment period.
We
observed that there was significant increase of Epidermal
Growth Factors (EGF)
expression in 14 as
shown in immunohistochemistry and
confirmed by western blot protein results.
Taken
together,
mangosteen peel extract-mediated changes in the
expression of growth factors in burned rat skins.
Mangosteen peel extract
might have a role in the acceleration of skin
wound healing.
To Cite This Article:
Gondokesumo ME, Pardjianto B, Handono K, Sumitro
SB, Widowati W,
Wismandanu O, Goenawan H, Hartady T, Rosdianto AM, Lesmana R, Wathoni N
and Supratman U, 2019. Garcinia Mangostana
extract enhances skin epithelialization in rat induced burn injury. Pak Vet J,
39(3): 365-370.
http://dx.doi.org/10.29261/pakvetj/2019.059
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ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)
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