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Autosomal Cholesterol Deficiency in a Holstein Calf

Joana Gonçalves Pontes Jacinto1, Marilena Bolcato1*, Cord Drögemüller2, Arcangelo Gentile1 and Gianfranco Militerno1

1Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra, 50-40064 Ozzano dell’Emilia (Bologna), Italy; 2Institute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstr. 109a-3001 Bern, Switzerland
*Corresponding author:


Cholesterol deficiency (CD) is an autosomal recessive defect in Holstein cattle caused by a mutation in the apolipoprotein B gene (APOB).  This paper reports the clinical and pathological phenotype of a case of CD in a 5-months-old Holstein calf. Retarded growth, chronic, intermittent diarrhea, stomatitis, hypocholesterolemia and low blood triglycerides concentrations were the most important clinical and ancillary findings. Histopathologically, inflammation of the digestive organs was the most evident sign. Blood from the patient, the dam, sister1, sister2 and semen of the sire were tested for APOB mutation: the calf resulted homozygous, whereas the dam and the sire resulted heterozygous carriers. Both sisters were APOB mutation free. Cholesterol deficiency should be considered in the differential diagnosis of chronic diarrhea and failure to thrive in Holstein calves.

To Cite This Article: Jacinto JGP, Bolcato M, Drögemüller C, Gentile A and Militerno G, 2020. Autosomal cholesterol deficiency in a Holstein calf. Pak Vet J, 40(2): 274-276.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)