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Integrins and Heparan Sulfate Play Crucial Role in Pathogenesis of Foot-and-Mouth Disease Virus

Muhammad Nauman Zahid1*, Muhammad Akbar Shahid2*, Hafiz Muhammad Imran3, Muhammad Oneeb3, Mushtaq Ahmed4, Zia Ur Rehman5, Nida Arooj6 and Tahir Yaqub3 

1Department of Biology, College of Science, University of Bahrain, Kingdom of Bahrain; 2Department of Pathobiology, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan, Pakistan; 3University of Veterinary and Animal Sciences, Lahore, Pakistan; 4Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan; 5University College of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur, Pakistan; 6Provincial Disease Diagnostic Laboratory, Lahore, Pakistan
*Corresponding author:;


Foot-and-mouth disease virus (FMDV) is one of highly contagious pathogens of cloven-footed animals, attaches with host cell surface receptors, including the integrins and heparan sulfate, for entry into the epithelial cells. FMDV is endemic in Pakistan, but limited studies are available on the interaction of local FMDV serotypes with host-entry factors. Here, we used anti-receptor antibodies and studied the interaction of Pakistani serotypes of FMDV serotypes (A, O and Asia-1) with integrins and heparan sulfate. We observed that by blocking integrins αvβ1, αvβ3 and αvβ6 as well as heparan sulfate by specific monoclonal antibodies, FMDV infection of serotype A, O and Asia-1 was prevented. In conclusion, anti-receptor antibodies are critically important to inhibit FMDV infection.

To Cite This Article: Zahid MN, Shahid MA, Imran HM, Oneeb M, Ahmed M, Rehman ZU, Arooj N and Yaqub T, 2020. Integrins and heparan sulfate play crucial role in pathogenesis of foot-and-mouth disease virus. Pak Vet J, 40(3): 403-406.  


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)