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Role of Oxidative Stress and Antioxidants in Thiram-induced Tibial Dyschondroplasia
Bingxian Liu, Ying Li, Khalid Mehmood2, Fazul Nabi3, Shakeel Ahmed4,5, Tauseef-ur-Rehman6, Mehwish Faheem7, Mariyam Ashraf8, Zhaoxin Tang1* and Hui Zhang1*
1College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; 2Department of Clinical Medicine and Surgery, Faculty of Veterinary and Animal Sciences, Islamia University of Bahawalpur, Pakistan; 3Lasbela University of Agriculture Water & Marine Sciences, Uthal Balochistan Pakistan; 4Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Campus Isla Teja, Valdivia (5090000), Chile; 5Lab of Foodomics, Institute of Food Science Research, (CIAL-CSIC), Universidad Autónoma de Madrid, Madrid, Spain; 6Department of Parasitology, Faculty of Veterinary and Animal Sciences, Islamia University of Bahawalpur, Pakistan; 7Department of Zoology, GC University, Lahore, Pakistan; 8The Islamia University of Bahawalpur, Pakistan
§These authors made equal contributions.
*Corresponding author:;


Tetramethyl thiuram disulfide (thiram) is an important dithiocarbamate bactericide; it has been widely used for the control of various diseases in fruits, vegetables, seeds and food grains. However, it also causes environmental pollution problems and poses a threat to human health to a certain extent. Thiram induces tibial dyschondroplasia (TD) by causing oxidative stress and antioxidants imbalance in tibial growth plate in poultry. TD is a skeletal abnormality in fast-growing poultry birds. It has been considered an economically important disease in poultry that affects poultry industry by carcass loss at meat processing plant due to decrease in disease resistance, production performance, and carcass quality and induces breast cysts and osteomyelitis worldwide. Oxidative stress is developed due to the imbalance of free radical oxygen, which disrupts the equilibrium state of oxidant and antioxidant tending to oxidation. This review is based on the current research, mainly to explore the relationship and mechanism between tibial dyschondroplasia and oxidative stress induced by thiram, which provides a new theoretical foundation for the further research of the related mechanism.

To Cite This Article: Liu B, Li Y, Mehmood K, Nabi F, Ahmed S, Tauseef-ur-Rehman, Faheem M, Ashraf M, Tang Z, Zhang H, 2021. Role of oxidative stress and antioxidants in thiram-induced tibial dyschondroplasia. Pak Vet J, 41(1): 1-6.  


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)