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Canine Disorder of Sex Differentiation
Hee-Ryung Lee1,2§, Gareeballah Osman Adam2,3#,  Dong Kwon Yang2, Sei-Jin Lee4, Hee-Seo Kim2,* and Shang-Jin Kim2*
1Hansarang Animal Hospital, Seoul, 02880, Republic of Korea; 2Department of Pharmacology, College of Veterinary Medicine, Jeonbuk National University, Iksan Campus, 79 Gobong-ro, Iksan-si, Jeollabuk-do 54596 Republic of Korea; 3Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, Sudan University of Science and Technology, P.O. Box No. 204, Hilat Kuku, Khartoum, Sudan; 4Korea Basic Science Institute Jeonju Center, Deokjin‑gu, Jeonju‑si, Jeollabuk‑do 54896, Republic of Korea
*Corresponding author: (HS Kim); (SJ Kim)
§These authors contributed equally to this work.


The disorder of the X chromosome causes defects in sex differentiation in the female phenotype. This work reports a six-month-old, Cocker Spaniel dog with intersex disorder diagnosed as pseudo-hermaphroditism. The dog was brought to the clinic with a swollen reddish penis-like protrusion, which was partially covered by the sheath. Clinical examination revealed the presence of raised nipple-like structures, resembling the nipples and extending from chest to groin region. However, the testes could not be detected. PCR analysis revealed the absence of the Y chromosome. A corrective surgery, including clitoridectomy, and removal of uterus and testicles-like structures, was performed. Histological examination of the removed organs showed underdeveloped testes and well-recognized endometrium. This report suggests that surgical correction may be used to overcome any possible complications in a six-month-old dog with pseudo-hermaphroditism.

To Cite This Article: Lee HR,  Adam GO,  Yang DK, Lee SJ, Kim HS and Kim SJ, 2020. Canine disorder of sex differentiation. Pak Vet J, 40(4): 540-542.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)