1Program
of Biomedical Science, Centre of Toxicology and Health Risk Study
(CORE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia,
Kuala Lumpur 50300, Malaysia; 2Department of
Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia,
Cheras, Kuala Lumpur 56000, Malaysia
*Corresponding author:
satirah@ukm.edu.my
Abstract
Estrogen level deteriorates in postmenopausal
women that is associated with increased risks of osteoporosis and cardiovascular
diseases. This study was aimed to investigate SAC supplementation effects on
vascular and bone health in ovariectomized rats. Twenty-four female Wistar rats
were randomly divided into 3 groups: sham, ovariectomy (OVX) and
SAC-supplemented OVX (OVX+SAC). Sixteen rats underwent OVX surgery (bilateral
ovaries excision) and 8 rats were sham-operated. After a 3-week recovery, sham
and OVX groups were given distilled water whereas OVX+SAC group was treated with
100 mg/kg SAC orally for 7 days. SAC supplementation showed a marked SBP
reduction (P<0.05) and a potential increase in NO production compared to OVX
group. However, SAC caused no changes in body weight increment, aortic and bone
oxidative stress markers, as well as in all bone parameters in OVX rats compared
to sham. SAC also sustained the increase (P<0.05) in intima-media thickness
(IMT); but ameliorated circumferential wall tension (CWT) in OVX rats. These
findings suggest that SAC supplementation may benefit the vascular health in the
postmenopausal animal model by reducing the SBP-raising effect, possibly by
modulating NO production.
To Cite This Article:
Halim RM, Kamisah Y, Aziz NF, Sudirman UN, Ahmad
NAN, Yong CK and Zainalabidin S, 2021. S-allylcysteine supplementation effects
on vascular and bone health in ovariectomized Wistar rats. Pak Vet J, 41(4):
507-512. http://dx.doi.org/10.29261/pakvetj/2021.118