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S-Allylcysteine Supplementation Effects on Vascular and Bone Health in Ovariectomized Wistar Rats
Rasyidah Mohamad Halim1, Yusof Kamisah2, Nurellya Faqhiraah Aziz1, Umi Nadhirah Sudirman1, Nor Anis Najwa Ahmad1, Chin Kok Yong2 and Satirah Zainalabidin1*

1Program of Biomedical Science, Centre of Toxicology and Health Risk Study (CORE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia; 2Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia
*Corresponding author:


Estrogen level deteriorates in postmenopausal women that is associated with increased risks of osteoporosis and cardiovascular diseases. This study was aimed to investigate SAC supplementation effects on vascular and bone health in ovariectomized rats. Twenty-four female Wistar rats were randomly divided into 3 groups: sham, ovariectomy (OVX) and SAC-supplemented OVX (OVX+SAC). Sixteen rats underwent OVX surgery (bilateral ovaries excision) and 8 rats were sham-operated. After a 3-week recovery, sham and OVX groups were given distilled water whereas OVX+SAC group was treated with 100 mg/kg SAC orally for 7 days. SAC supplementation showed a marked SBP reduction (P<0.05) and a potential increase in NO production compared to OVX group. However, SAC caused no changes in body weight increment, aortic and bone oxidative stress markers, as well as in all bone parameters in OVX rats compared to sham. SAC also sustained the increase (P<0.05) in intima-media thickness (IMT); but ameliorated circumferential wall tension (CWT) in OVX rats. These findings suggest that SAC supplementation may benefit the vascular health in the postmenopausal animal model by reducing the SBP-raising effect, possibly by modulating NO production.

To Cite This Article: Halim RM, Kamisah Y, Aziz NF, Sudirman UN, Ahmad NAN, Yong CK and Zainalabidin S, 2021. S-allylcysteine supplementation effects on vascular and bone health in ovariectomized Wistar rats. Pak Vet J, 41(4): 507-512.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)