Orientin Attenuates Cisplatin-Induced Renal
Toxicity by Reducing Oxidative Stress and Inflammation
Muhammad Umar Ijaz1, Sidra Aziz1,
Mehwish Faheem2, Khalid Abbas1, Shabab Nasir3,
Huma Naz4, Akash Ali1, Tauseef ur Rehmn5
and Muhammad Imran6*
1Department
of Zoology, Wildlife and Fisheries, University of Agriculture,
Faisalabad, Pakistan
2Department
of Zoology, Government College University, Lahore, Pakistan
3Department
of Zoology, Government College University, Faisalabad, Pakistan
4Department
of Zoology, Cholistan University of Veterinary and Animal Sciences,
Bahawalpur, Pakistan 4Department
of Zoology, Cholistan University of Veterinary and Animal Sciences,
Bahawalpur, Pakistan
5Department
of Parasitology, Faculty of Veterinary and Animal Sciences, The
Islamia University of Bahawalpur, Pakistan
6Department
of Parasitology, University of Agriculture, Faisalabad, Pakistan
*Corresponding author:
imran.asghar@uaf.edu.pk
Abstract
Cisplatin (CP), an effective chemotherapeutic drug, has been widely used to
treat the several types of tumors. Orientin (ORI) is a flavonoid that shows
versatile therapeutic activities.
The current research was planned to observe the protective role ORI on CP
induced renal injury in rats. Twenty-four male rats were divided into four
groups equally and termed as control, CP (10 mg/kg), CP (10 mg/kg) + ORI (40
mg/kg) and ORI (40 mg/kg). After seven days trial, rats were dissected and
different parameters were analyzed. Results indicated that the CP administration
significantly reduced the activities of catalase, peroxidase, glutathione
reductase and glutathione content whereas it increased the level of hydrogen
peroxide and TBARS (thiobarbituric acid reactive substances). CP increased the
creatinine and urea levels while decreased the creatinine clearance. Moreover,
CP significantly increased the inflammatory markers, including nuclear factor
kappa-B, tumor necrosis factor-α, Interleukin-6, Interleukin-1β levels,
cyclooxygenase-2 activity and histopathological damages. However,
co-administration of ORI displayed curative effects against CP-induced renal
toxicity and recovered all parameters by bringing them to a normal level. These
results revealed that the ORI is a potential bioflavonoid that can potentially
counter the CP-induced renal damage.
To Cite This Article:
Ijaz MU, Aziz S, Faheem M, Abbas K, Nasir S, Naz
H, Ali A, Rehman T and Imran M, 2021. Orientin attenuates cisplatin-induced
renal toxicity by reducing oxidative stress and inflammation. Pak Vet J, 41(4):
574-578. http://dx.doi.org/10.29261/pakvetj/2021.076