PAKISTAN
VETERINARY
JOURNAL
     
 
previous page   Pak Vet J, 2021, 41(4): 574-578   next page
 
Orientin Attenuates Cisplatin-Induced Renal Toxicity by Reducing Oxidative Stress and Inflammation
 
Muhammad Umar Ijaz1, Sidra Aziz1, Mehwish Faheem2, Khalid Abbas1, Shabab Nasir3, Huma Naz4, Akash Ali1, Tauseef ur Rehmn5 and Muhammad Imran6*
 

1Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan
2Department of Zoology, Government College University, Lahore, Pakistan
3Department of Zoology, Government College University, Faisalabad, Pakistan
4Department of Zoology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
4Department of Zoology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
5Department of Parasitology, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Pakistan
6Department of Parasitology, University of Agriculture, Faisalabad, Pakistan
*Corresponding author: imran.asghar@uaf.edu.pk

Abstract   

Cisplatin (CP), an effective chemotherapeutic drug, has been widely used to treat the several types of tumors. Orientin (ORI) is a flavonoid that shows versatile therapeutic activities.  The current research was planned to observe the protective role ORI on CP induced renal injury in rats. Twenty-four male rats were divided into four groups equally and termed as control, CP (10 mg/kg), CP (10 mg/kg) + ORI (40 mg/kg) and ORI (40 mg/kg). After seven days trial, rats were dissected and different parameters were analyzed. Results indicated that the CP administration significantly reduced the activities of catalase, peroxidase, glutathione reductase and glutathione content whereas it increased the level of hydrogen peroxide and TBARS (thiobarbituric acid reactive substances). CP increased the creatinine and urea levels while decreased the creatinine clearance. Moreover, CP significantly increased the inflammatory markers, including nuclear factor kappa-B, tumor necrosis factor-α, Interleukin-6, Interleukin-1β levels, cyclooxygenase-2 activity and histopathological damages. However, co-administration of ORI displayed curative effects against CP-induced renal toxicity and recovered all parameters by bringing them to a normal level. These results revealed that the ORI is a potential bioflavonoid that can potentially counter the CP-induced renal damage.

To Cite This Article: Ijaz MU, Aziz S, Faheem M, Abbas K, Nasir S, Naz H, Ali A, Rehman T and Imran M, 2021. Orientin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation. Pak Vet J, 41(4): 574-578. http://dx.doi.org/10.29261/pakvetj/2021.076

 
   
 

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)



scopus
 
DOI
 
DOAJ SEAL