Nephroprotective Effects of Delphinidin against Bisphenol A Induced
Kidney Damage in Rats
Kaynat Alvi1, Muhammad Umar Ijaz1, Ali Hamza1,
Asma Ashraf2, Jessica Arooj2 and Nazia Ehsan1*
1Department
of Zoology, Wildlife and Fisheries, University of Agriculture,
Faisalabad, Pakistan
2Department
of Zoology, Government College, University, Faisalabad
*Corresponding author:
nazia.ehsan@uaf.edu.pk
Abstract
Bisphenol A (BPA) is a hazardous industrial pollutant that has the potential to
induce renal toxicity. Delphinidin (Del) is an anthocyanidin that displays
versatile pharmacological properties. The study was designed to access the
ameliorative role of Del on BPA-instigated renal impairment. Twenty-four
Sprague-Dawley rats were distributed into four groups and the experiment was
conducted in triplicate. Group I was designated as a control group (0.1% DMSO),
while group II was orally administrated with 10 mg/kg of BPA. Groups III
received BPA + Del (10 mg/kg + 25 mg/kg), whereas group IV was treated with Del
(25 mg/kg) orally. After the completion of thirty days’ experiment, all the rats
were euthanized and various parameters were evaluated. The findings of our
research showed that administration of BPA tremendously decreased the activities
of catalase, glutathione peroxidase, superoxide dismutase, glutathione reductase,
glutathione-S-transferaseas well as reduced the level of glutathione,
while it increased the malondialdehyde level. The production of reactive oxygen
species also increased after BPA exposure. Moreover, BPA exposure caused
substantial elevation in urea and creatinine levels, with significantly low
creatinine clearance. Furthermore, BPA remarkably escalated the inflammatory
markers level (interleukin-1β, nuclear factor kappa-B, interleukin-6, tumor
necrosis factor-α, as well as cyclooxygenase-2 activity) and caused
histopathological damage. Del + BPA co-treatment showed renoprotective effects
against BPA-induced damages by restoring all the parameters. Collectively, the
treatment of Del showed a remedial role against the nephrotoxic effects of BPA
that might be linked with its antioxidant and anti-inflammatory properties.
To Cite This Article:
Alvi K, Ijaz MU, Hamza A, Ashraf A, Arooj J and Ehsan N,
2022. Nephroprotective effects of
delphinidin against bisphenol a induced kidney damage in rats. Pak Vet J.
http://dx.doi.org/10.29261/pakvetj/2022.085