Malignant catarrhal fever (MCF) is a fatal disease caused by a Macavirus of the Herpesviridae family that affects even-toed ungulates worldwide. The two most important subgroups are Alcelaphine gammaherpesvirus-1 (AlVH-1) and Ovine gammaherpesvirus-2 (OvHV-2). MCF, in Mexico, is considered an exotic disease according to the "Agreement classifying mandatory notifiable exotic and endemic diseases and plagues in terrestrial and aquatic animals in the United Mexican States". This study was undertaken in 2018 on a teaching farm in the Mexican Highlands with affected sheep, goats, cows, and deer, all with ulcerative lesions varying from minor to severe. Some animals were officially diagnosed as positive for OvHV-2 using semi-nested PCR by the organization responsible for such diagnoses in Mexico. The principal lesions observed include ulcerative and erosive lesions in the oral cavity and digestive tract; corneal opacity; interdigital fold lesions; and lymphadenomegaly. This represents an outbreak of OvHV-2-associated MCF in Mexico confirmed by WOAH-approved diagnostic tests.