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Fasciolosis: Recent Update in Vaccines Development and Their Efficacy

Tauseef ur Rehman1*, Fahmy Gad Elsaid2, Maria Magdalena Garijo Toledo3, Arcangelo Gentile4, Riaz Ahmed Gul1, Muhammad Rashid1, Muhammad Tahir Aleem5,6 and Muhammad Arfan Zaman7

1Department of Parasitology, The Islamia University of Bahawalpur, Pakistan
2Biology Department, College of Science, King Khalid University, Asir, Abha, Al-Faraa, P.O. Box: 960-Postal Code: 61421, Saudi Arabia; 3Department of Animal Production and Health, Public Veterinary Health and Food Science and Technology, Faculty of Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities. Calle Tirant lo Blanc, 7, 46115, Valencia, Spain; 4Department of Veterinary Medical Sciences, University of Bologna, Italy
5MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P.R. China; 6Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH 44115, USA
7Department of Pathobiology, College of Veterinary and Animal Sciences, Jhang
*Corresponding author:


Fasciolosis is caused by F. hepatica and F. gigantica. It is of economic and zoonotic importance. Several strategies for control of fasciolosis are being used; these include vaccination of animals that are at risk and control of the snails that carry the parasite. Several types of vaccines, such as recombinant cathepsin, mixed recombinant vaccine, fatty-acid-binding proteins, a cocktail of recombinant and fatty-acid-binding vaccines, nucleic acid-based vaccines and gene-silencing methods have been reported to show efficacy ranges of 32-75%, 52-79%, 8-36%, 43-68%, 74-100% and 90% respectively. These are currently undergoing experimental testing against fasciolosis. The study described in this paper was carried out to discover the comparative efficacy of these vaccines in the enhancement of the immune response in order to find the most effective method so that future research could focus on the development of that type of vaccine. Besides immunization, control of the intermediate host of the parasite (snail) is also an effective way to control fasciolosis. Snails are controlled through the use of physical, chemical and biological methods. The most effective of these is biological control using Sphaerodema urinator as a predator of snails.

To Cite This Article: Rehman TU, Elsaid FG, Toledo MMG, Gentile A, Gul RA, Rashid M, Aleem MT and Zaman MA, 2023. Fasciolosis: recent update in vaccines development and their efficacy. Pak Vet J, 43(2): 224-231.  


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)