The current study demonstrates the immunomodulatory properties of Carica papaya extract to counter experimental coccidiosis. For this purpose, one hundred and seventy-five chicks were placed into 05 groups to evaluate immunomodulatory effects of C. papaya extract. At 7^th day, chicks of all groups were fed with sporulated oocysts of different Eimeria species. Members of groups A, B and C were treated with three doses of C. papaya extract (100, 200, and 300 mg/kg of body weight) distinctly. Members of group D were fed with Vitamin-E and served as positive control while Group E was treated with PBS and served as negative Control Group. PHA-P, Carbon Clearance Assay, CON-A and Dinitrochlorobenzene tests were performed for the evaluation of cell mediated immune response. Humoral immune response was evaluated by performing hemagglutination test. Statistical analyses revealed that groups treated with C. papaya extract had a stronger cellular and humoral response against coccidiosis. However, the immunological response was excellent in the group treated with C. papaya extract at dose rate of 300mg. This shows the potential of C. papaya to be used in coccidiosis control programs, but further studies are required to evaluate its complete potential as anticoccidial agent.